Hormones | Their Role In Fat Loss

Written by Jamie Bantleman

Hormones and Their Role In Fat Loss

Fat loss, the most complex topic in the health and fitness world, with 101 different ideas, opinions and experts you must ensure your plan in place is fool proof and able to drive you towards your end goal.


In this latest article on health and fitness, we are going to discuss hormones and their role in fat loss. The key hormones in fat loss are:

body fat




“Ghrelin is one of the main hormones to stimulate hunger. Ghrelin levels increase before meals and decrease after meals, a mechanism that has its roots in the hypothalamus. If the lateral hypothalamus is removed (as seen in animal studies), feeding becomes less frequent leading to severe weight loss and death. If the ventromedial hypothalamus is removed, feeding increases, leading to weight gain and severe obesity.”



“Leptin is a well-known ‘adipokine’ (signalling molecule made in body fat) that acts as a nutrient sensor, and increases metabolic rate during periods of overfeeding; its secretion is sensitive to carbohydrate ingestion, and its elevation during dieting desired.”

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The hormone that in regards to bodybuilding is detrimental (if elevated) due to the role it plays around the muscle cell. It causes muscular atrophy which is the exact opposite to what you should be looking to achieve in an efficient and effective off season. Cortisol isn’t always viewed in a negative light due to its vital role it plays when waking the body up in the morning and also when preparing the body for exercise.


When we gain unnecessary weight, cortisol will spike due to insulin imbalances that are being forced through the poor diet choices of high sugars.



A hormone made mainly in the testes (part of the male reproductive system). It is needed to develop and maintain male sex characteristics, such as facial hair, deep voice, and muscle growth. Testosterone may also be made in the laboratory and is used to treat certain medical conditions.


When your body fat increases testosterone is reduced in the body therefore your ability to gain muscle mass will be compromised. A major part of a bodybuilders thinking in the off season is that they put as much muscle mass on as possible however if testosterone is effected you will not find gaining quality muscle mass an easy task.


Equally fat gain will have an impact on one’s cortisol levels.

reducing body fat



The female hormone that regulates the reproductive hormones alongside metabolic processes such as bone growth and cholesterol levels. It can also mediate fat metabolism and cognition.


However an excess in estrogen can lead to an increase in body fat percentage.





Our articles should be used for informational and educational purposes only and are not intended to be taken as medical advice. If you’re concerned, consult a health professional before taking dietary supplements or introducing any major changes to your diet.

Faye Reid

Faye Reid

Writer and expert

Faye Reid has a Bachelor of Science in Sport and Exercise Physiology and a Master of Science in Exercise Physiology and Sports Nutrition. Faye has worked with numerous high-profile organisations, such as Men's Health, Sky Sports, Huddersfield Giants, Warrington Wolves, British Dressage and GB Rowing, providing her expert sports science support. Find out more about Faye's experience here: She puts her passion into practice as goal attack for her netball team, and in competitive event riding.

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