What Is Trans Resveratrol? | Benefits, Side Effects, Dosage

By Christopher Tack |

Clinical Specialist Physiotherapist

Resveratrol is the reason behind the notion that drinking red wine can be positive for your health!

This polyphenol compound found in the skin of grapes has the science world in a tizzy as researchers from Harvard University have shown that mice fed with resveratrol amazingly had a 25% greater life expectancy than similar mice, and did not gain weight when given a high fat and high calorie diet (compared to controls) (1).

If you are interested in the secret behind a longer life or perhaps a magical weight loss cure, read on and learn about resveratrol.


Polyphenols are a specific group of plant compounds which have been deemed to have positive health benefits. There are approximately 8,000 types in nature, of which resveratrol is one (2).

These molecules are generally found in the skin of plants and work to protect them from environmental stress. Through a concept of xenohormesis, plants respond to stress by changing at a molecular level (such as the accumulation of resveratrol in the plants skin), which then leads to induction of a biologically beneficial and protective response in the animals which have consumed the plant (3-6).

What Is Trans Resveratrol?

Trans-resveratrol is one of the isomers (molecule structures) of resveratrol, with cis-resveratrol being the other. Simply put, trans-resveratrol occurs with hydroxide atoms on opposite sides of the molecule, where cis- resveratrol has the hydroxide atoms on the same side.

Trans- resveratrol is deemed to have the greater biological activity of the two isomers (7).redwine

Interest in resveratrol stems partially from the cardioprotective effects of drinking red wine (8).

Researchers postulate that a higher than average wine consumption in this population may protect them from having cardiology issues (9), and informs the extensive research into the components of wine to discover which elements provide this protective effect.

In 1992, resveratrol was examined more closely and identified as a key component of grape skin for this function (10-11).

Since this discovery, further research has been undertaken showing that resveratrol also shows anti-inflammatory and anti-oxidant effects; as well as an amazing ability to extend the lifespan in various animals (12).

What does Trans Resveratrol do? Benefits?

The health benefits of resveratrol are widespread and through various mechanisms this compound has been shown to affect a number of illnesses.

#1 Anti-oxidant

Firstly, a number of the systemic effects which resveratrol provides are through its capacity as an anti-oxidant and anti-inflammatory agent (16).

For example, resveratrol has the ability to induce activity of a key protein (PGC-1?) which results in greater mitochondrial development in our body’s tissue (e.g. muscle, brain, heart) to reduce oxidative stress (17-18).

With more mitochondria available in muscle more oxygen can be delivered to aid oxidative phosphorylation, which can assist exercise endurance performance.


For example: in animal studies, resveratrol has been shown to increase treadmill running time to exhaustion (17). Similarly, in healthy humans resveratrol supplementation has been seen to increase cardiovascular efficiency during exercise (19-20).

#2 Neuroprotection

Alongside the benefits to the cardiovascular system, resveratrol has also been seen to have a protective effect on the nervous system.

For a number of degenerative neurological conditions resveratrol seems to have a benefit in preventing degenerative changes.


Resveratrol influences a variety of metabolic pathways to reduce the number and size of these protein plaque deposits by repressing p53 activity and the aforementioned changes to nuclear factor kappa B activation- the net result of which decreases neurodegenerative toxins to protect nerve and brain cells (34).

#3 Aging

Probably one of the most amazing physiological mechanisms provided by resveratrol is related to its remarkable effect on the aging process. This mechanism revolves around a distinct group of enzymes called sirtuins.

It is thought that the main function of these enzymes is in the promotion of survival and resistance to stress (44), and in some lower animal forms (yeast, worms and flies) the genes which encode sirtuins are associated with longer life (45-47). Incredibly this association is also seen in mammals (7).

Sources of Trans Resveratrol?

As already stated wine is a common source of resveratrol, however in this sense not all wine is created equally.

Red wine (e.g. Pinot Noir) has a concentration of resveratrol up to 14mg per litre (7), whilst white wine has less than 0.1mg per litre. This would indicate the importance of grape colour when choosing a source of this compound.

However, even a red grape juice only contains 0.5mg per litre and a whole grape contains 3.54?g per gram, thus indicating the importance of the concentration of resveratrol within the skin which is accentuated and accumulated in the wine making process.

Other sources of resveratrol are peanuts (maximum 1.92?g per gram) and the herb Japanese Knotweed which has a concentration of 0.524mg per gram (13).

Side Effects and Safety

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Studies examining the pharmacological mechanisms and effects of resveratrol show that supplementation is very safe for humans. For example, one particular study (52) showed that 5g of resveratrol daily showed no adverse effects.

Similar results were seen in another study (53) which supported the use of 4g per day for a period of 3 months with no side effects.

Take Home Message

Admittedly, the purpose of this article is not to convince you of the potential for resveratrol to boost your chances to achieve eternal life.

Instead it’s biological mechanisms are presented to highlight the sophisticated and astonishing benefits this compound can provide to aid your cardiovascular, metabolic and neurological health. I think these are all good reasons for why everyone should consider trying resveratrol.

Many thanks,



What is Trans-veratrol?

Trans-veratrol is one of the isomers of resveratrol, researched to have anti-inlammatory and anti-oxidant properties.

What are the benefits of Trans-veratrol?

Trans-veratrol has been researched to have a number of properties, including anti-inflammatory, neuroprotective and anti aging.

What are sources of trans-veratrol?

Red wine, peanuts, and japanese knotweed have all been found to contain trans-veratrol.

What are the side effects of trans-veratrol?

There have been no adverse side effects attributed to the intake of trans-veratrol.


Our articles should be used for informational and educational purposes only and are not intended to be taken as medical advice. If you’re concerned, consult a health professional before taking dietary supplements or introducing any major changes to your diet.


Casey Walker

Casey Walker

Experienced Sports Nutrition Technologist

Casey Walker is an experienced sports nutrition new product development technologist. He holds a Bachelor of Science in Sports and Exercise Science and a Master of Science in Sports Sciences and Physiology.

Casey’s scientific research area of expertise lies in the effects of dietary nitrates on sprint performance and exercise-induced muscle damage. He has also worked as a sports scientist for a medal-winning Paralympic track cyclist, with a goal of qualifying for the Rio 2016 Paralympics.

Find out more about Casey’s experience here.

In his spare time, Casey is a keen middle-distance runner with an interest in triathlon. He’s always looking out for the latest blends and supplements to improve his half-marathon time and recovery.

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