Supplements

Vitamin E Supplements | Benefits, Deficiency Symptoms & Food Sources

 
Back in 1912 a Polish bio-scientist named Casimir Funk was examining deficiency diseases and why certain animals failed to thrive. After reading that eating brown rice may reduce the chance of suffering a nutritional deficiency disease, he examined rice in an attempt to isolate the substance which prevented such disorders.

He succeeded in isolating a “factor” in the rice, which he described as amine (like an amino acid). As he deemed the said factor “vital to life” he coined the term vitamin e – which later was modified to vitamin!

Between 1910 and 1920, starting with the work of American chemist Cornelia Kennedy, these vitamins were enumerated with a letter in order to designate differences between them. The first five vitamins discovered were labelled A, B, C, D and finally (the subject of this article)- Vitamin E.


What is Vitamin E?

 
mixed nuts

Vitamin E is a naturally occurring substance which is a collective group of fat-soluble compounds. It is also the most potent, fat soluble anti-oxidant which floats around in human plasma.

This group actually consists of 8 chemically different forms which have differing degree of activity on a biological level. These are phenols (carbolic acids) which are methylated (derived from methane); and are called tocopherols and tocotrienols.

Four tocopherols and four tocotrienols are each labelled alpha-, beta-, gamma- and delta-, to make up the Vitamin E family.

Thankfully for us alpha (ά) tocopherol (or formally 2,5,7,8-tetramethyl-2R- (40R,80R,12 trimethyltridecyl)-6-chromanol) is the only one which is considered to meet human requirements (1). This is largely due to the fact that the liver uses a specific protein (ά-tocopherol transfer protein) to re-secrete this form, whilst metabolising and excreting the others (2). Supplement labels may display the name D-a-tocopherol or RRR-a-tocopherol, which practically are the same thing.


Sources of Vitamin E

 
nut butters

Diet

Vitamin E can be consumed through both dietary means and supplementation.

The best food sources of vitamin E (ά-tocopherol) are nuts, seeds and oils. For example, wheat germ oil has 20.3mg of ά-tocopherol per tablespoon. Alternately, you could get 7.4mg in one ounce of dry roasted sunflower seeds; 6.8mg per ounce of almonds; or 1.45mg per tablespoon of peanut butter. Leafy, green vegetables; other whole grains and nuts; and fortified cereals are also sources of ά-tocopherol.

Western diets consume the majority of their vitamin E in the form of gamma (γ) tocopherol from soybean, corn and predominantly polyunsaturated vegetable oils (3).

Estimations of vitamin E consumption from food are often calculated in terms of “ά-tocopherol equivalents” (ά-TEs). This is where γ-tocopherol content can be used as a substitute for ά-tocopherol with an efficiency of 10% (e.g. 10 γ-tocopherol molecules equals 1 ά-TE). The issue with calculating vitamin E consumption via this method is flawed however, as γ-tocopherol is not equivalent functionally; does not convert to ά-tocopherol; and essentially is too easily depleted from our body. If you only followed ά-TEs, then the amount of vitamin E you calculate consumed would be over estimated.

Supplements

Supplements often are sold as esters, which are chemical compounds which protect ά-tocopherol from oxidation and prolong shelf life. If your supplement is labelled D- ά-tocopherol or dl- ά-tocopherol, then these would be forms of natural or synthetic ά-tocopherol, respectively. The synthetic forms (dl-) contain equal amounts of the 8 different vitamin E compounds and are only half as active as the same amount of natural ά-tocopherol (4); although are just as easily absorbed (1).

Most supplements provide ≥100 international units (IU) of vitamin E. Vitamins are usually measured in IUs as different forms of the vitamin will have different biological activity; and a standardized unit allows supplement labels to accurately display the degree of “active” compound for the user.

1 IU is biologically equivalent to 0.67mg d- ά-tocopherol or 0.9mg of dl- ά-tocopherol.

Studies examining the consumption of vitamins have shown that 11.3% of people take vitamin E supplements containing up to 400IU (5).


Are You Deficient in Vitamin E?

 
panda2

Prevalence

Historically national surveys find that most western diets provide less than the recommended levels of vitamin E (6,7). Realistically these estimations are likely not a true depiction of how much is consumed by the average healthy adult (1); however a predisposition toward reducing fat in weight loss diets may lead to insufficiencies in intake across populations whom are substituting with fat free foods (6). The reduction in fat consumed means a lesser amount of ά-tocopherol, however “insufficiency” in your diet does NOT mean deficiency is apparent.

True vitamin E deficiency is quite rare in humans and is almost never caused by a sub-optimal intake (1). Instead vitamin E deficiency is more often a result of developmental or genetic predispositions; for example, in babies born very prematurely and of very low birth weight (<1.5kg). These infants may be prone to retina development issues, or a higher risk of infection (8).

Other genetic causes include protein-energy malnutrition (where either there is a lack of sufficient protein or calories in the diet); abnormalities in/ deficiency of ά-tocopherol transfer protein (such as in Ataxia and Vitamin E deficiency [AVED] syndrome); or secondary to fat malabsorption syndromes (such as abetalipoproteinemia where the intestine is unable to absorb fats to hold vitamin E).

In fact this latter group is one which has a much higher rate of deficiency than the standard population. These and other conditions, such as Crohn’s disease or cystic fibrosis patients, sometimes supplement with a water (rather than fat) soluble form of vitamin E to ensure its increase consumption (9).

Symptoms

Despite the cause (for example, AVED or abetalipoproteinemia) the main symptoms of vitamin E deficiency lead to a presentation of peripheral neuropathy and neuromuscular related dysfunction (10). This is due to the degeneration of large nerve bodies when ά-tocopherol is absent.

This nerve dysfunction can lead to myopathy (weakness secondary to reduced muscle innervation); ataxia (loss of movement control); loss of vision; and impaired immune response (10, 11, 12).

However, as a physiotherapist I must advise that there are much more common reasons for these types of symptoms and one should not be too quick to self diagnose with a vitamin E deficiency!

KIRK MILLER ABBY PELL ABS WORKOUT

Anti-Oxidant Properties

As I have already stated the predominant benefit from ensuring a sufficient intake of vitamin E is due to its anti-oxidant properties.

Vitamin E is the most potent, fat soluble of all vitamins, and as such protects polyunsaturated fatty acids in phospholipids and plasma lipoproteins. This provides the advantage of preventing damage to cell membranes.

In fact, when a free (peroxyl) radical is let loose in a cell membrane it is 1000 times more likely to attack a vitamin E molecule, rather than the polyunsaturated acids in the cell (13).

The vitamin E molecule acts as a chain-breaking antioxidant by reacting with the free peroxyl radical to form a lipid hydroperoxide and a tocopheroxyl radical. This secondary radical atom is then easier disposed of without causing further destruction.

This cellular protection potentially can benefit disease states where chronic oxidative stress is a pathological factor. These may include heart disease, cancer, eye disorders and cognitive decline.

HEART DISEASE
CANCER
EYE DISORDERS
COGNITIVE DECLINE

Vitamin E and Athletic Performance

 
WORKOUT training routine

The question remains whether vitamin E intake can benefit athletes and gym goers, beyond the protection against disease and age related oxidative stress.

In healthy individuals who exercise and perform sports, oxidative stress is actually a component to the overload during training we utilise to cause muscular adaptations and build bigger, stronger muscles.

Muscular contraction itself is associated with reactive oxygen species (free radicals) (39), and whilst we aim to minimise these atoms through anti-oxidants, they also provide a benefit.

A small amount of free radical molecules, such as nitric oxide or hydrogen peroxide, work as signalling molecules to activate the redox-sensitive signalling pathway (39). This can in turn lead to cellular adaptations, remodelling and growth in trained muscle.

As such there have been concerns that consumption of anti-oxidant supplements could potentially blunt the effects of exercise training by modification of cellular signalling pathways.

ATHLETE STUDIES

cycling triathlon programme

What does this mean for the average athlete interested in consuming an anti-oxidant such as vitamin E?

It means that a supplement such as this will not blunt the effect of exercise training, but will still act in a protective manner for your health.

In addition, some groups will benefit more by this supplement. For example, studies demonstrate that for those training at 1525m altitude, aerobic work capacity increased by 8.9%, and at 4570m increased by 14.2%; in those given 1200IU of vitamin E for 6 weeks (42). These results were also supported by another study which showed increases in anaerobic threshold in high altitude mountain climbers given a 10 week course of 400mg per day of vitamin E (43).

Interestingly, despite a great depth of research, it is also suggested that other groups, such as those overtraining, may benefit from the ergogenic effect of vitamin E. It may be that it can attenuate fatigue during performance (44); and that glucose tolerance, insulin action and lipoprotein status may all be improved (45).


Vitamin E and Skin Care

 
No discussion of vitamin E is complete without consideration of its benefits to the health of skin and aging. The skin has a larger amount of reactive oxygen species than any other organ, and in no area are the negative effects of oxidative stress to cause aging more apparent (46).

The oxidative stress caused by free radicals has been deemed one of the key contributors to aging (47-48); and ά-tocopherol has an important photoprotective and anti-photoaging role in skin health (49). These benefits are due not only to the anti-oxidant behaviour of vitamin E but also by its ability to modify signalling pathways to counteract the effects of the suns rays (50-51). This can be through consumption of a supplement or via cutaneous application (52).


Side effects/safety

 
vitamin e side effects

The upper limit of supplement consumption has been designated at 1000 mg/ day as a safe dose in most individuals; a level which would be almost impossible to reach by just eating food (13).

There have been studies which demonstrate a risk in all-cause mortality by consuming less than this dosage (400-569 IU per day) (53-54).

The main side effects of ά-tocopherol supplements are haemorrhage and excessive bleeding (55-56) which may occur when the supplementary upper limit intake is consistently overconsumed.


Take Home Message

 
Vitamin E (ά-tocopherol) has a number of uses due to its powerful anti-oxidant effect. It can help protect against diseases and aging which are caused by reactive oxygen species damaging our cells; but seems to not influence similar mechanisms we will use to facilitate exercise adaptations.

In some groups there is even an ergogenic effect, particularly for those training endurance at high altitude. Therefore you can be safe in the knowledge that vitamin E can protect your health; and not only will it not blunt your gains, but it may also boost your performance.

Many thanks,

Chris

REFERENCES

 

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Myprotein

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