Uses Of 5-HTP Supplements | Benefits, Dosage & Side Effects

The benefits of 5-hydroxytrytophan, or 5-HTP, are thought to be therapeutic rather than ergogenic. In essence, this substance is more of a pseudo-medication than a supplement, and we'll investigate its potential benefits of using it in this article.

So, strap in and enjoy the biochemical roller coaster which is 5-HTP.

• What is 5-HTP?
• What is Serotonin?
• Why Do I Care About Serotonin?
• 5-HTP Supplements for Weight Loss?
• 5-HTP Supplements As a Sleep Aid?
• Can 5-HTP Supplements Relieve Pain?
• What About Joint Health?
• 5-HTP Supplements | Recommended Dosage
• 5-HTP Supplements | Safety/Side Effects

What is 5-HTP?

5-HTP is not an amino acid. However, it is made from the amino acid L-tryptophan, which naturally occurs in protein foods (e.g. turkey and milk).

5-HTP is not however in the food we eat, and as such needs either to be manufactured from L-tryptophan or consumed as a supplement. It's usually produced from a particular West African herb called Griffonia simplicifolia. This shrub contains approximately 20% 5-HTP which can be sourced for supplement uses.

So why do we want to consume 5-HTP? The answer: serotonin.

What is Serotonin?

You may have heard of serotonin (or 5-hydroxytryptamine), which is a neurotransmitter used by the central nervous system, and has a role in many functions, including sleep regulation, depression and anxiety. It has been described as a “happy chemical” due to its relationship with mood¹.

Often, people diagnosed with depression are prescribed a medication called SSRIs (selective serotonin re-uptake inhibitors), which ensure sufficient amounts of serotonin are available for the brain and nervous system to use. These medications in effect stop absorption (or transfer) of serotonin from a synapse (a junction between two nerves) into an adjacent cell, leaving more of the chemical available to bind to receptors.

5-HTP is a precursor to the production of serotonin⁵, which means it's a required component for its biochemical synthesis in the body. 5-HTP is converted into serotonin via a chemical reaction caused by an enzyme called aromatic L-amino acid decarboxylase (AAAD).

This is important because taking serotonin itself as a medication is not effective, as this neurotransmitter cannot pass the blood-brain barrier and be used by the brain. 5-HTP, however, can pass the brain barrier².

You can either consume L-tryptophan (which is then converted to 5-HTP, but would cost energy) or to consume 5-HTP itself in supplement form.

Consuming L-tryptophan alone is affected by other amino acids in the intestine during absorption, which uses this amino acid to produce proteins and attenuates its ability to produce serotonin. 5-HTP does not require a transport molecule and as such is not affected the same during absorption.

When taken as an oral supplement, approximately 70% has been found to end up in the blood stream to be converted to serotonin^3,4.

Why do I care about serotonin?

The use of 5-HTP as a serotonin booster for anti-depressive therapy has been examined²⁰ but is not strictly our focus here.

Many of the readers of this article are perfectly happy and have lives which do not require an extra serotonin boost. However, anti-depressant properties are only a few of the benefits that have been suggested for 5-HTP.

Studies have researched 5-HTP for diverse problems such as pain disorders, binge eating associated with obesity, and even insomnia.

5-HTP Supplements for weight loss?

A number of sources describe the dietary benefits of consuming 5-HTP to assist weight loss.

For example, one study⁶ used a double-blind crossover study design to evaluate 19 obese females with BMI scores of between 30 and 40. The participants were either given either a daily 8mg of a 5-HTP supplement per kg of bodyweight, a dose of L-tryptophan or placebo, for 5 weeks. Their diet was otherwise not altered or restricted.

They measured the participants' feeding behaviour using a questionnaire, and their food intake via a 3-day food diary. When they examined their results, they found that 5-HTP both reduced food intake and triggered greater weight loss than placebo.

In fact, they saw a three times greater rate of effectiveness compared to L-tryptophan and placebo. They concluded that the serotonin increase (whilst making no change to mood state) increased satiety (fullness) rather than reduction in appetite.

Further studies

Another study(7) used a similar double-blind study design and evaluated the effectiveness of 900mg 5-HTP daily versus a placebo supplement in a group of 20 obese participants. The researchers followed the groups over 2 consecutive 6 week periods to measure effectiveness over a longer duration of time.

During period one (the first six weeks), they gave no dietary restrictions, and during period two (the second six weeks) they recommended a 1,200kcal diet. Their results were just as striking. They observed firstly a reduction in carbohydrate intake and also early satiety in the 5-HTP group. This led to a reduction of body mass on average of 4.7kg in this 5-HTP group across both periods, which was 4.5% bodyweight reduction. In the placebo group only a 1.3% reduction was seen.

The reduction during period 1 in the 5-HTP group was 1.5%, and in period 2 was 3%, each of which were greater than that seen in the placebo group during the entire trial. In animal studies, food intake has been seen to be dose-dependent to the amount of 5-HTP consumed⁸; and results have been replicated in trials with participants who had type 2 diabetes⁹.

Additionally, the mechanism of overeating induced by stress has been found to be reduced by 5-HTP supplementation¹⁰, which may highlight the benefits of reducing this negative food-related behaviour to diminish over eating therapeutically¹¹.

5-HTP supplements as a sleep aid?

It's widely recognised that various neurotransmitters (including serotonin) assist modulation of our sleep cycle. Early evidence has suggested that serotonin, specifically, may influence our ability to fall asleep.

Mostly, studies describe how serotonin assists our ability to stay awake and function while awake. Serotonin works with other chemicals, such as acetylcholine and noradrenaline, to promote brain responsiveness, and inhibits the parts of the brainstem which promote sleep¹².

Why 5-HTP, which boosts serotonin, as a sleep aid?

Other studies demonstrate that if you use a chemical called parachlorophenylalanine (PCPA) to reduce brain levels of serotonin, then the result is insomnia¹³. Further studies show that this effect can be reversed by consumption of 5-HTP¹⁴.

This can be explained due to the relationship between serotonin and a specific phase of our sleep cycle: REM sleep. REM, which stands for rapid eye movement, sleep is a component of our sleep cycle characterised by random movements of the eyes and REM atonia (which is normal muscle paralysis during sleep). This is also the stage where we dream most vividly and dreams following consumption of 5-HTP are often reported to be very clear.

REM sleep deprivation can lead to depression, anger and eating disorders(16). It usually comprises between 5-20% of our sleep cycle¹⁷.

However, research has previously shown that taking 5-HTP can cause an increase in the duration of REM sleep from 5% of the entire cycle to 53%¹⁷.

The absolute muscle relaxation which occurs during this stage means better recovery and feelings of wakefulness upon getting out of bed. In a way, it allows us to fully prepare for being awake, as such improving our behavioural and physiological process efficiency when awake.

5-HTP also has also been shown in scientific studies to have additional sleep-related benefits. These include reducing the time required to get to sleep¹⁸, reducing the number of times you awake at night(18), increasing the duration of sleep, and improving the quality of sleep¹⁹.